Structure–activity relationships of bipyridine inotropic cardiac agents

Classification of positive inotropic agents.

Although there is increasing recognition that all inotropic agents are not alike, they continue to be viewed in the generic sense because of the lack of a classification system. Analogous to the classification system proposed for the antiarrhythmic agents over 20 years ago, a classification system is proposed that categorizes inotropic agents according to their mechanisms of action. Agents are ...

Clinical use of inotropic agents.

Inotropic support during cardiac surgery.

extremely claustrophobic conditions, the nature of the patient's illness, and the requirements for patient compliance during the procedure followed by a rapid recovery. There is a paucity of information on how this can ideally be achieved. Propofol would appear to satisfy these requirements, but its unpredictable effects on involuntary movements precludes its use. The regimen suggested by Dr Gr...

Cardiac effects of non-adrenergic inotropic drugs

Cover illustration " Weighing of the Heart " from chapter 125 of " the Book of the Dead " , a famous papyrus from the 19th Dynasty of the New Kingdom in ancient Egypt, dated around 1250 BC. Second thoughts Tage Danielsson from " Thoughts from the root " (1974) I believe in doubt. Doubt is the basis of all knowledge and the engine of all change. Doubt is, to make doubly sure, the prerequisite of...

Role of inotropic agents in the treatment of heart failure.

Systolic heart failure (HF) is a systemic disease caused by reduced cardiac contractility. Although it would seem logical that this disease could be treated with strategies to directly improve contractility, inotropic therapies in the HF population have universally failed to live up to their expectations. Paradoxically, favorable outcomes can be achieved by administering drugs that may transien...